Product ID:L-HISTIDINE, FREEBASE, 3810
MSDS Date:03/31/1999
FSC:6505
NIIN:00N092488
Status Code:A
MSDS Number: CJTCM

Emergency Phone: 800-424-9300

Info Phone: 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

L-HISTIDINE, FREE BASE

CAS: 71-00-1

RTECS: MS3070000

LD50 LC50 Mixture:LD50: (ORAL,RAT) >15 G/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. CHRONIC: THERE IS LIMITED
EVIDENCE THAT L-HISTIDINE, FREE BASE IS MUTAGENIC IN LABORATORY
CELL CULTURES. UNTIL FURTHER TESTIN G HAS BEEN DONE, IT SHOULD BE
TREATED AS A POSSIBLE MUTAGEN IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:IN CASES OF SKIN CONT, WASH W/AND COPIOUS AMTS OF WATER FOR
AT LST 15 MINS. REMOVE CONTAMD CLTHG & SHOES & WASH BEFORE WEARING.
CONSULT PHYSICIAN. IN CASES OF EYE CONT, FLUSH W/COPIOUS AMTS OF
WATER F OR AT LST 15 MINS. ASSURE ADEQ FLUSHING BY SEPARATING
EYELIDS W/FINGERS. CONSULT PHYSICIAN. IN CASES OF INHALATION,
REMOVE TO FRESH AIR & MONITOR BREATHING. IF BRTHG BECOMES DFCLT,
GIVE OXYG & CONSULT PHYSICIAN. IF BRTHG STOPS, GIVE ARTF RESP &
CONSULT PHYSICIAN. IN CASES OF INGESTION, WASH MOUTH OUT W/WATER &
CONSULT LOCAL POISON CENTER AND PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN
AND EYES.
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPRVD RESP, CHEM
SAFETY GOGGLES, RUBBER BOOTS, AND HEAVY RUBBER GLOVES. SWEEP UP AND
PLACE IN SUITABLE CONTAINER. AVOID RAISING DUST. HOLD FOR
APPROPRIATE DISPOSAL. WASH SPI LL SITE & VENTILATE AREA AFTER
MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN TIGHTLY CLOSED CONTAINER IN
COOL, DRY PLACE (+20C). POSSIBLE MUTAGEN. AVOID CONTACT W/MATERIAL.
AVOID PROLONGED OR REPEATED EXPOSURE.
Other Precautions:LAB SHOULD BE EQUIPPED WITH A SAFETY SHOWER AND AN
EYE WASH STATION. WASH THOROUGHLY AFTER HANDLING MATERIAL.

Respiratory Protection:USE NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
TOX INFO: REFER TO REGISTRY OF TOXIC EFTS OF CHEM SUBSTANCE (RTECS) FOR
DEFINITION OF ABBREVIATIONS USED IN ABOVE TEXT & FOR ADDNL INFO.
THIS REPORT CNTNS ONLY SELECTED INFO FROM RTECS.

Solubility in Water:SOLUBLE
Appearance and Odor:WHITE SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, AND LOCAL REGULATIONS
ARE VARIED & CHANGE FREQUENTLY. FOR THIS REASON, WE RECOMMEND THAT
YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR INFO ON
DISPOSAL OF THIS PROD UCT OR ARRANGE FOR DISPOSAL BY LICENSED
DISPOSAL COMPANY.

Toxicological Information:RTECS NUMBER: MS3070000. TOX DATA &
REFERENCES: ORL/RAT;LD50: >15 G/KG. ORL;MUS;LD50: >15 G/KG.
IPR;RAT;LD50: >8 G/KG. IPR;MUS;LD50: >10 G/KG. IVN;RAT;LD50: >2
G/KG. IVN;MUS;LD50: >2 G/KG. SCU;RAT;LD5 0: >10 G/KG. SCU;MUS;
LD50: >10 G/KG. ALL ARE 1981. GEKKAN YAKUJI. PHARMACEUTICALS
MONTHLY. 23, 1253. GENETIC DATA & REFERENCES: OTH;HMN;DOSE: 1
MMOL/L DNA INHIBITION 1975. JOURNAL OF INVESTIGATIVE DE RMATOLOGY.
65, 400. LNG;HAM;DOSE: 2500 PPM CYTOGENETIC ANALYSIS 1985. TOX
LETTERS. 28, 117. LYM;HMN;DOSE: 10 MG/L SISTER CHROMATID EXCHANGE
1992. MUTATION RESEARCH. 280,279. (SUPDAT)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
CLASS: N/A. IATA PACKING GROUP: N/A.

Federal Regulatory Information:XN. RISK PHRASES: R40: POSSIBLE RISK OF
IRREVERSIBLE EFFECTS. SAFETY PHRASES: S22: DO NOT BREATHE DUST.
S24/25: AVOID CONTACT WITH SKIN AND EYES. S36/37/39: WEAR SUITABLE
PROTECTIVE CLOTHING, GLOVES A ND EYE/FACE PROTECTON. S45: IN CAS OF
ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY.